期刊文章 - 基礎科學
中心特設此欄目以方便大家尋索本港的愛滋病病毒/愛滋病研究刊物和研究結果。如 閣下發表了有關愛滋病病毒/愛滋病的期刊文章或摘要,並希望將它們放置於此欄目內,請以電郵與我們聯絡 rrc@dh.gov.hk。
2022
- 這連結會以新視窗打開。Chen SMY, Wong YC, Yim LY, Zhang H, Wang H, Lui GCY, Li X, Tang X, Cheng L, Du Y, Peng Q, Wang J, Kwok HY, Huang H, Lau TT, Chan DPC, Wong BCK, Liu L, Chakrabarti LA, Lee SS, Chen Z. Enhanced Cross-Reactive and Polyfunctional Effector-Memory T Cell Responses by ICVAX-a Human PD1-Based Bivalent HIV-1 Gag-p41 Mosaic DNA Vaccine J Virol. 2022 Apr 13;96(7):e0216121. doi: 10.1128/jvi.02161-21. Epub 2022 Mar 17.
- 這連結會以新視窗打開。Hagberg L, Edén A, Zetterberg H, Price RW, Gisslén M. Blood biomarkers for HIV infection with focus on neurologic complications-A review Acta Neurol Scand. 2022 Jul;146(1):56-60. doi: 10.1111/ane.13629. Epub 2022 Apr 26.
- 這連結會以新視窗打開。Yang G, Li J, Leung CK, Shen B, Wang C, Xu Y, Lin S, Zhang S, Tan Y, Zhang H, Zeng X, Hong S, Li L. Methamphetamine and HIV-1 Tat proteins synergistically induce microglial autophagy via activation of the Nrf2/NQO1/HO-1 signal pathway Neuropharmacology. 2022 Dec 1;220:109256. doi: 10.1016/j.neuropharm.2022.109256. Epub 2022 Sep 24.
- 這連結會以新視窗打開。Zhao F, Fung TY, Chen Z, Wang H, Cheung AKL. Association of human cytomegalovirus in urine with end-organ diseases in stage 2/3 HIV-1-infected individuals J Clin Virol. 2023 Jan;158:105351. doi: 10.1016/j.jcv.2022.105351. Epub 2022 Dec 11.
2021
- 這連結會以新視窗打開。Li R, Qi Y, Shi L, Wang W, Zhang A, Luo Y, Kung WK, Jiao Z, Liu G, Li H, Zhang L. Brain Volumetric Alterations in Preclinical HIV-Associated Neurocognitive Disorder Using Automatic Brain Quantification and Segmentation Tool. Front Neurosci. 2021 Aug 11;15:713760. doi: 10.3389/fnins.2021.713760. eCollection 2021.
- 這連結會以新視窗打開。Wong YC, Liu W, Yim LY, Li X, Wang H, Yue M, Niu M, Cheng L, Ling L, Du Y, Chen SMY, Cheung KW, Wang H, Tang X, Tang J, Zhang H, Song Y, Chakrabarti LA, Chen Z. Sustained viremia suppression by SHIVSF162P3CN-recalled effector-memory CD8+ T cells after PD1-based vaccination PLoS Pathog. 2021 Jun 14;17(6):e1009647. doi: 10.1371/journal.ppat.1009647. eCollection 2021 Jun.
- 這連結會以新視窗打開。Huang J, Zhang R, Wang S, Zhang D, Leung CK, Yang G, Li Y, Liu L, Xu Y, Lin S, Wang C, Zeng X, Li J. Methamphetamine and HIV-Tat Protein Synergistically Induce Oxidative Stress and Blood-Brain Barrier Damage via Transient Receptor Potential Melastatin 2 Channel Front Pharmacol. 2021 Mar 17;12:619436. doi: 10.3389/fphar.2021.619436. eCollection 2021.
- 這連結會以新視窗打開。Li J, Huang J, He Y, Wang W, Leung CK, Zhang D, Zhang R, Wang S, Li Y, Liu L, Zeng X, Li Z. The protective effect of gastrodin against the synergistic effect of HIV-Tat protein and METH on the blood-brain barrier via glucose transporter 1 and glucose transporter 3 Toxicol Res (Camb). 2021 Jan 22;10(1):91-101. doi: 10.1093/toxres/tfaa102. eCollection 2021 Jan.
2020
- 這連結會以新視窗打開。Tang X, Zhang S, Peng Q, Ling L, Shi H, Liu Y, Cheng L, Xu L, Cheng L, Chakrabarti LA, Chen Z, Wang H, Zhang Z. Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection. Sci Adv. 2020 Feb 19;6(8):eaaz0374. doi: 10.1126/sciadv.aaz0374. eCollection 2020 Feb.
- 這連結會以新視窗打開。Zeng X, Tsui JC, Shi M, Peng J, Cao CY, Kan LL, Lau CP, Liang Y, Wang L, Liu L, Chen Z, Tsui SK. Genome-Wide Characterization of Host Transcriptional and Epigenetic Alterations During HIV Infection of T Lymphocytes. Front Immunol. 2020 Sep 10;11:2131. doi: 10.3389/fimmu.2020.02131. eCollection 2020.
- 這連結會以新視窗打開。Liu L, Lin Q, Peng J, Fang J, Tan Z, Tang H, Kwan K, Nishiura K, Liang J, Kwok H, Du Z, Sun J, Liu K, Yuen KY, Wang H, Chen Z. Persistent lentivirus infection induces early myeloid suppressor cells expansion to subvert protective memory CD8 T cell response. EBioMedicine. 2020 Oct;60:103008. doi: 10.1016/j.ebiom.2020.103008. Epub 2020 Sep 24.
2019
- 這連結會以新視窗打開。Xu XY, Wang DY, Ku CF, Zhao Y, Cheng H, Liu KL, Rong LJ, Zhang HJ. Anti-HIV lignans from Justicia procumbens. Chin J Nat Med. 2019 Dec;17(12):945-952. doi: 10.1016/S1875-5364(19)30117-7.
- 這連結會以新視窗打開。Ryang J, Yan Y, Song Y, Liu F, Ng TB. Anti-HIV, antitumor and immunomodulatory activities of paclitaxel from fermentation broth using molecular imprinting technique. AMB Express. 2019 Dec 3;9(1):194. doi: 10.1186/s13568-019-0915-1.
- 這連結會以新視窗打開。Cheung AKL, Huang Y, Chen M, Chen ZW. Transfer of HIV-1 from HIV-1 latently infected CD34+ haematopoietic progenitors to CD4+ T cells. Hong Kong Med J. 2019 Oct;25 Suppl 7(5):37-40.
- 這連結會以新視窗打開。Zhuang K, Zhang Y, Zhou L, Qi X, Xu X, Meng F, Xu Z, Liu J, Shao L, Liu H, Liu H, Fang J, Deng D, Peng J, Zhou F, Liu L, Tang H, Xiong Y, Ho W, Guo D, Ke H, Gui X. Isolation and characterization of spontaneously immortalized B-lymphocyte lines from HIV-infected patients with and without non-Hodgkin's Lymphoma. Cancer Med. 2019 Nov;8(15):6741-6755. doi: 10.1002/cam4.2508. Epub 2019 Sep 20.
- 這連結會以新視窗打開。Ahmed SF, Quadeer AA, Morales-Jimenez D, McKay MR. Sub-dominant principal components inform new vaccine targets for HIV Gag. Bioinformatics. 2019 Oct 15;35(20):3884-3889. doi: 10.1093/bioinformatics/btz524.
- 這連結會以新視窗打開。Ling L, Wu T, To KKW, Cheung KW, Lui KOL, Niu M, Lam KS, Wang CC, Li J, Wang H, Yuen KY, Chen Z. Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice. AIDS. 2019 Mar 15;33(4):F1-F12. doi: 10.1097/QAD.0000000000002149.
- 這連結會以新視窗打開。Cui H, Geng W, Sun H, Han X, An M, Jiang Y, Zhang Z, Chen Z, Xu J, Hu Q, Zhao B, Zhou B, Shang H. Rapid CD4+ T-cell decline is associated with coreceptor switch among MSM primarily infected with HIV-1 CRF01_AE in Northeast China. AIDS. 2019 Jan 27;33(1):13-22. doi: 10.1097/QAD.0000000000001981.
2018
- 這連結會以新視窗打開。Chen Z. Monkey Models and HIV Vaccine Research. Adv Exp Med Biol. 2018;1075:97-124. doi: 10.1007/978-981-13-0484-2_5. (Search PubMed)
- 這連結會以新視窗打開。Cheung KW, Wu T, Ho SF, Wong YC, Liu L, Wang H, Chen Z. α4β7+ CD4+ Effector/Effector Memory T Cells Differentiate into Productively and Latently Infected Central Memory T Cells by Transforming Growth Factor β1 during HIV-1 Infection. J Virol. 2018 Mar 28;92(8). pii: e01510-17. doi: 10.1128/JVI.01510-17. Print 2018 Apr 15. (Search PubMed)
- 這連結會以新視窗打開。Li J, Wang W, Tong P, Leung CK, Yang G, Li Z, Li N, Sun X, Han Y, Lu C, Kuang D, Dai J, Zeng X. Autophagy Induction by HIV-Tat and Methamphetamine in Primary Midbrain Neuronal Cells of Tree Shrews via the mTOR Signaling and ATG5/ATG7 Pathway. Front Neurosci. 2018 Dec 6;12:921. doi: 10.3389/fnins.2018.00921. eCollection 2018. (Search PubMed)
- 這連結會以新視窗打開。Liu W, Wong YC, Chen SMY, Tang J, Wang H, Cheung AKL, Chen Z. DNA prime/MVTT boost regimen with HIV-1 mosaic Gag enhances the potency of antigen-specific immune responses. Vaccine. 2018 Jul 25;36(31):4621-4632. doi: 10.1016/j.vaccine.2018.06.047. Epub 2018 Jun 28. (Search PubMed)
- 這連結會以新視窗打開。Louie RHY, Kaczorowski KJ, Barton JP, Chakraborty AK, McKay MR. Fitness landscape of the human immunodeficiency virus envelope protein that is targeted by antibodies. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E564-E573. doi: 10.1073/pnas.1717765115. Epub 2018 Jan 8.
- 這連結會以新視窗打開。Pasayan MKU, Mationg MLS, Boettiger D, Lam W, Zhang F, Wen-Wei Ku S, Merati TP, Chaiwarith R, Cuong DD, Yunihastuti E, Kiertiburanakul S, Van Kinh N, Avihingsanon A, Sun LP, Kamarulzaman A, Kantipong P, Kumarasamy N, Pujari S, Heng Sim BL, Ng OT, Choi JY, Tanuma J, Ross J, Ditangco R. Effect of Macrolide Prophylactic Therapy on AIDS-Defining Conditions and HIV-Associated Mortality. J Acquir Immune Defic Syndr. 2018 Dec 10. doi: 10.1097/QAI.0000000000001933. [Epub ahead of print] (Search PubMed)
- 這連結會以新視窗打開。Quadeer AA, Morales-Jimenez D, McKay MR. Co-evolution networks of HIV/HCV are modular with direct association to structure and function. PLoS Comput Biol. 2018 Sep 7;14(9):e1006409. doi: 10.1371/journal.pcbi.1006409. eCollection 2018 Sep. (Search PubMed)
- 這連結會以新視窗打開。Sun Z, Yan L, Tang J, Qian Q, Lenberg J, Zhu D, Liu W, Wu K, Wang Y, Lu S. Brief introduction of current technologies in isolation of broadly neutralizing HIV-1 antibodies. Virus Res. 2018 Jan 2;243:75-82. doi: 10.1016/j.virusres.2017.10.011. Epub 2017 Oct 16. Review. (Search PubMed)
- 這連結會以新視窗打開。Tsang HF, Chan LW, Tong JC, Wong HT, Lai CK, Au TC, Chan AK, Ng LP, Cho WC, Wong SC. Implementation and new insights in molecular diagnostics for HIV infection. Expert Rev Mol Diagn. 2018 May;18(5):433-441. doi: 10.1080/14737159.2018.1464393. Epub 2018 Apr 19. (Search PubMed)
- 這連結會以新視窗打開。Wang Q, Wong CH, Chan HYE, Lee WY, Zuo Z. Statistical Design of Experiment (DoE) based development and optimization of DB213 in situ thermosensitive gel for intranasal delivery. Int J Pharm. 2018 Mar 25;539(1-2):50-57. doi: 10.1016/j.ijpharm.2018.01.032. Epub 2018 Jan 31. (Search PubMed)
- 這連結會以新視窗打開。Wu X, Guo J, Niu M, An M, Liu L, Wang H, Jin X, Zhang Q, Lam KS, Wu T, Wang H, Wang Q, Du Y, Li J, Cheng L, Tang HY, Shang H, Zhang L, Zhou P, Chen Z. Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. J Clin Invest. 2018 Jun 1;128(6):2239-2251. doi: 10.1172/JCI96764. Epub 2018 Apr 23.
- 這連結會以新視窗打開。Yang Z, Liu X, Sun Z, Li J, Tan W, Yu W, Zhang M. Identification of a HIV Gp41-Specific Human Monoclonal Antibody With Potent Antibody-Dependent Cellular Cytotoxicity. Front Immunol. 2018 Nov 16;9:2613. doi: 10.3389/fimmu.2018.02613. eCollection 2018. (Search PubMed)
- 這連結會以新視窗打開。Yew WW, Chan DP, Singhal A, Zhang Y, Lee SS. Does oxidative stress contribute to adverse outcomes in HIV-associated TB? J Antimicrob Chemother. 2018 May 1;73(5):1117-1120. doi: 10.1093/jac/dkx509. (Search PubMed)
- 這連結會以新視窗打開。Zeng XF, Li Q, Li J, Wong N, Li Z, Huang J, Yang G, Sham PC, Li SB, Lu G. HIV-1 Tat and methamphetamine co-induced oxidative cellular injury is mitigated by N-acetylcysteine amide (NACA) through rectifying mTOR signaling. Toxicol Lett. 2018 Dec 15;299:159-171. doi: 10.1016/j.toxlet.2018.09.009. Epub 2018 Sep 24. (Search PubMed)
- 這連結會以新視窗打開。Zhao Y, Lin L, Xiao Z, Li M, Wu X, Li W, Li X, Zhao Q, Wu Y, Zhang H, Yin J, Zhang L, Cho CH, Shen J. Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application. J Immunol Res. 2018 Jul 10;2018:5081634. doi: 10.1155/2018/5081634. eCollection 2018. Review. (Search PubMed)
2017
- 這連結會以新視窗打開。Cheung AKL, Kwok HY, Huang Y, Chen M, Mo Y, Wu X, Lam KS, Kong HK, Lau TCK, Zhou J, Li J, Cheng L, Kiat Lee B, Peng Q, Lu X, An M, Wang H, Shang H, Zhou B, Wu H, Xu A, Yuen KY, Chen Z. Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection. Nat Microbiol. 2017 Oct;2(10):1389-1402. doi: 10.1038/s41564-017-0006-5. Epub 2017 Aug 14. (Search PubMed)
- 這連結會以新視窗打開。Sun Z, Lu S, Yang Z, Li J, Zhang MY. Construction of a recombinant full-length membrane associated IgG library. Virus Res. 2017 Jun 15;238:156-163. doi: 10.1016/j.virusres.2017.06.018. Epub 2017 Jun 24. (Search PubMed)
- 這連結會以新視窗打開。Cheung AKL, Huang Y, Kwok HY, Chen M, Chen Z. Latent human cytomegalovirus enhances HIV-1 infection in CD34+ progenitor cells. Blood Adv. 2017 Jan 16;1(5):306-318. doi: 10.1182/bloodadvances.2016000638. eCollection 2017 Jan 24. (Search PubMed)
- 這連結會以新視窗打開。Tang X, Guo J, Cheng L, Sun C, Liu L, Zuo T, Wang H, Chen L, Zhang L, Chen Z. Single N277A substitution in C2 of simian immunodeficiency virus envelope influences vaccine-elicited CD4i neutralizing and anti-V2 antibody responses. Vaccine. 2017 May 2;35(19):2582-2591. doi: 10.1016/j.vaccine.2017.03.062. Epub 2017 Mar 31. (Search PubMed)
- 這連結會以新視窗打開。Zhang HJ, Rumschlag-Booms E, Guan YF, Wang DY, Liu KL, Li WF, Nguyen VH, Cuong NM, Soejarto DD, Fong HHS, Rong L. Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa. J Nat Prod. 2017 Jun 23;80(6):1798-1807. doi: 10.1021/acs.jnatprod.7b00004. Epub 2017 Jun 14. (Search PubMed)
- 這連結會以新視窗打開。Wang Y, Lin HQ, Wang P, Hu JS1, Ip TM, Yang LM, Zheng YT, Chi-Cheong Wan D. Discovery of a Novel HIV-1 Integrase/p75 Interacting Inhibitor by Docking Screening, Biochemical Assay, and in Vitro Studies. J Chem Inf Model. 2017 Sep 25;57(9):2336-2343. doi: 10.1021/acs.jcim.7b00402. Epub 2017 Sep 11. (Search PubMed)
- 這連結會以新視窗打開。Wang Q, Zhang Y, Wong CH, Edwin Chan HY, Zuo Z. Demonstration of Direct Nose-to-Brain Transport of Unbound HIV-1 Replication Inhibitor DB213 Via Intranasal Administration by Pharmacokinetic Modeling. AAPS J. 2017 Dec 27;20(1):23. doi: 10.1208/s12248-017-0179-0. (Search PubMed)
- 這連結會以新視窗打開。Jou E, Gligich O, Chan AC, Mohan D, Felsen UR, Ayyappan S, Billett HH, Hui EP, Chan AT, Raghupathy R. Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients. Hematol Oncol. 2017 Mar;35(1):64-68. doi: 10.1002/hon.2247. Epub 2015 Jul 24. (Search PubMed)
- 這連結會以新視窗打開。Liu F, Wang Y, Zhang K, Wang Y, Zhou R, Zeng Y, Han Y, Ng TB. A novel polysaccharide with antioxidant, HIV protease inhibiting and HIV integrase inhibiting activities from Fomitiporia punctata (P. karst.) murrill (Basidiomycota, hymenochaetales). Int J Biol Macromol. 2017 Apr;97:339-347. doi: 10.1016/j.ijbiomac.2017.01.030. Epub 2017 Jan 12. (Search PubMed)
- 這連結會以新視窗打開。Sun Z, Lu S, Yang Z, Li J, Zhang M. Isolation and characterization of an HIV-1 envelope glycoprotein-specific B-cell from an immortalized human naïve B-cell library. J Gen Virol. 2017 Apr;98(4):791-798. doi: 10.1099/jgv.0.000706. Epub 2017 Apr 13. (Search PubMed)
- 這連結會以新視窗打開。Zhang HJ, Rumschlag-Booms E, Guan YF, Liu KL, Wang DY, Li WF, Nguyen VH, Cuong NM, Soejarto DD, Fong HHS, Rong L. Anti-HIV diphyllin glycosides from Justicia gendarussa. Phytochemistry. 2017 Apr;136:94-100. doi: 10.1016/j.phytochem.2017.01.005. Epub 2017 Jan 19. (Search PubMed)
2016
- 這連結會以新視窗打開。Cheung KW, Peng Q, He L, Cai K, Jiang Q, Zhou B, To SW, Yam WC, Liu L, Chen Z, Wang H. Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System. PLoS One. 2016 Apr 19;11(4):e0153641. doi: 10.1371/journal.pone.0153641. eCollection 2016. (Search PubMed)
- 這連結會以新視窗打開。Wang Q, Zhang Y, Qian S, Peng S, Zhang Q, Wong CH, Chan HY, Zuo Z. Pharmacokinetics and brain uptake of HIV-1 replication inhibitor DB213 in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Jun 5;125:41-7. doi: 10.1016/j.jpba.2016.03.025. Epub 2016 Mar 14. (Search PubMed)
- 這連結會以新視窗打開。Zhang XM, Zhang Q, Wu H, Lau TC, Liu X, Chu H, Zhang K, Zhou J, Chen ZW, Jin DY, Zheng BJ. Novel Mutations L228I and Y232H Cause Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Combinational Pattern. AIDS Res Hum Retroviruses. 2016 Sep;32(9):909-17. doi: 10.1089/AID.2015.0359. Epub 2016 May 9. (Search PubMed)
- 這連結會以新視窗打開。Au KY, Shi WW, Qian S, Zuo Z, Shaw PC. Improvement of the Pharmacological Properties of Maize RIP by Cysteine-Specific PEGylation. Toxins (Basel). 2016 Oct 17;8(10). pii: E298. (Search PubMed)
- 這連結會以新視窗打開。Liu L, Wang W, Matz J, Ye C, Bracq L, Delon J, Kimata JT, Chen Z, Benichou S, Zhou P. The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1. J Virol. 2016 Nov 14;90(23):10642-10659. Print 2016 Dec 1. (Search PubMed)
- 這連結會以新視窗打開。Guan Y, Wang D, Tan GT, Van Hung N, Cuong NM, Pezzuto JM, Fong HH, Soejarto DD, Zhang H. Litsea Species as Potential Antiviral Plant Sources. Am J Chin Med. 2016;44(2):275-90. doi: 10.1142/S0192415X16500166. (Search PubMed)
2015
- 這連結會以新視窗打開。Zhang Y, Li SK, Yang KY, Liu M, Lee N, Tang X, Wang H, Liu L, Chen Z, Zhang C, Wang J, Tsui KWS. Whole genome methylation array reveals the down-regulation of IGFBP6 and SATB2 by HIV-1. Scientific Reports. 2015 Jun 3;5:10806. doi: 10.1038/srep10806. (Search PMC)
- 這連結會以新視窗打開。Zhang Y, Li SK, Tsui SK. Genome-wide analysis of DNA methylation associated with HIV infection based on a pair of monozygotic twins. Genomics Data. 2015 Jul 30;6:12-5. doi: 10.1016/j.gdata.2015.07.024. eCollection 2015. (Search PMC)
- 這連結會以新視窗打開。Ng TB, Cheung RC, Wong JH, Wang Y, Ip DT, Wan DC, Xia J. Antiviral activities of whey proteins. Applied Microbiology and Biotechnology. 2015 Sep;99(17):6997-7008. doi: 10.1007/s00253-015-6818-4. Epub 2015 Jul 22. (Search PubMed)
- 這連結會以新視窗打開。Ng TB, Cheung RC, Wong JH, Chan WY. Proteins, peptides, polysaccharides, and nucleotides with inhibitory activity on human immunodeficiency virus and its enzymes. Applied Microbiology and Biotechnology. 2015 Dec;99(24):10399-414. doi: 10.1007/s00253-015-6997-z. Epub 2015 Sep 28. (Search PubMed)
2014
- 這連結會以新視窗打開。Wu H, Zhang X, Zhang H, Zhang Q, Chen Z, Huang J, Lee S, Zheng B. In Vitro Selection of HIV-1 CRF08_BC Variants Resistant to Reverse Transcriptase Inhibitors. AIDS Res Hum Retroviruses. 2014 Dec 6. [Epub ahead of print] (Search PubMed)
- 這連結會以新視窗打開。Wong JH, Liu Z, Law KW, Liu F, Xia L, Wan DC, Ng TB. A study of effects of peptide fragments of bovine and human lactoferrins on activities of three key HIV-1 enzymes. Peptides. 2014 Nov 1;62C:183-188. doi: 10.1016/j.peptides.2014.07.006. [Epub ahead of print] (Search PubMed)
- 這連結會以新視窗打開。Gu WG, Zhang X, Ip DT, Yang LM, Zheng YT, Wan DC. Discovery of a novel HIV-1 integrase inhibitor from natural compounds through structure based virtual screening and cell imaging. FEBS Lett. 2014 Sep 17;588(18):3461-8. doi: 10.1016/j.febslet.2014.08.004. Epub 2014 Aug 13. (Search PubMed)
- 這連結會以新視窗打開。Gu WG, Ip DT, Liu SJ, Chan JH, Wang Y, Zhang X, Zheng YT, Wan DC.1,4-Bis(5-(naphthalen-1-yl)thiophen-2-yl)naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens epithelium-derived growth factor. Chem Biol Interact. 2014 Apr 25;213:21-7. doi: 10.1016/j.cbi.2014.01.011. Epub 2014 Jan 28. (Search PubMed)
- 這連結會以新視窗打開。Zhang L, Zhu C, Guo Y, Wei F, Lu J, Qin J, Banerjee S, Wang J, Shang H, Verma SC, Yuan Z, Robertson ES, Cai Q. Inhibition of KAP1 enhances hypoxia-induced Kaposi's sarcoma-associated herpesvirus reactivation through RBP-Jκ. J Virol. 2014 Jun;88(12):6873-84. doi: 10.1128/JVI.00283-14. Epub 2014 Apr 2. (Search PMC)
- 這連結會以新視窗打開。Pan W, Liu K, Guan Y, Tan GT, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HH, Zhang H. Bioactive compounds from Vitex leptobotrys. J Nat Prod. 2014 Mar 28;77(3):663-7. doi: 10.1021/np400779v. Epub 2014 Jan 9. (Search PubMed)
- 這連結會以新視窗打開。Au KY, Wang RR, Wong YT, Wong KB, Zheng YT, Shaw PC. Engineering a switch-on peptide to ricin A chain for increasing its specificity towards HIV-infected cells. Biochim Biophys Acta. 2014 Mar;1840(3):958-63. doi: 10.1016/j.bbagen.2013.11.005. Epub 2013 Nov 15. (Search PubMed)
- 這連結會以新視窗打開。Zhang X, Huang SZ, Gu WG, Yang LM, Chen H, Zheng CB, Zhao YX, Wan DC, Zheng YT. Wikstroelide M potently inhibits HIV replication by targeting reverse transcriptase and integrase nuclear translocation. Chin J Nat Med. 2014 Mar;12(3):186-93. doi: 10.1016/S1875-5364(14)60031-5. (Search PubMed)
- 這連結會以新視窗打開。Wang CR, Zhou R, Ng TB, Wong JH, Qiao WT, Liu F. First report on isolation of methyl gallate with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibitory activities from a mushroom (Pholiota adiposa). Environ Toxicol Pharmacol. 2014 Mar;37(2):626-37. doi: 10.1016/j.etap.2014.01.023. Epub 2014 Feb 3. (Search PubMed)
- 這連結會以新視窗打開。Yi L, Zhao J, Lu J, Chen Y, Chen L, Cheng J, Sun Y, Li Z, Men R, Yang L, Kung H, Yang Z1, He ML. Gene expression profiling of CD4⁺ T cells in treatment-naive HIV, HCV mono- or co-infected Chinese. . Virol J. 2014 Feb 13;11:27. doi: 10.1186/1743-422X-11-27. (Search PMC)
- 這連結會以新視窗打開。Naftalin CM, Chan KC, Wong KH, Cheung SW, Chan RC, Lee SS. CYP2B6-G516T genotype influences plasma efavirenz concentration in a Hong Kong population, allowing potential individualization of therapy.HIV Med. 2014 Jan;15(1):63-4. doi: 10.1111/hiv.12076. (Search PubMed)
2013
- 這連結會以新視窗打開。Lin P, Wong JH, Ng TB, Ho VS, Xia L. A sorghum xylanase inhibitor-like protein with highly potent antifungal, antitumor and HIV-1 reverse transcriptase inhibitory activities. Food Chem. 2013 Dec 1;141(3):2916-22. doi: 10.1016/j.foodchem.2013.04.013. Epub 2013 Jun 5. (Search PubMed)
- 這連結會以新視窗打開。Au KY, Wang RR, Wong YT, Wong KB, Zheng YT, Shaw PC. Engineering a switch-on peptide to ricin A chain for increasing its specificity towards HIV-infected cells. Biochim Biophys Acta. 2013 Nov 15. pii: S0304-4165(13)00488-1. doi: 10.1016/j.bbagen.2013.11.005. (Search PubMed)
- 這連結會以新視窗打開。Zhang Y, Yuan T, Li J, Zhang Y, Xu J, Shao Y, Chen Z, Zhang MY. The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development. AIDS. 2013 Oct 23;27(16):2529-39. doi: 10.1097/QAD.0000000000000015. (Search PubMed)
- 這連結會以新視窗打開。To SW, Chen JH, Wong KH, Chan KC, Ng HM, Wu H, Lam JT, Yam WC. Performance comparison of an in-house integrase genotyping assay versus the ViroSeq™ Integra48, and study of HIV-1 integrase polymorphisms in Hong Kong. J Clin Virol. 2013 Sep;58(1):299-302. doi: 10.1016/j.jcv.2013.06.040. Epub 2013 Jul 22. (Search PubMed)
- 這連結會以新視窗打開。Yuan T, Li J, Zhang MY. HIV-1 envelope glycoprotein variable loops are indispensable for envelope structural integrity and virus entry. PLoS One. 2013 Aug 1;8(8):e69789. doi: 10.1371/journal.pone.0069789. Print 2013. (Search PubMed)
- 這連結會以新視窗打開。To SW, Chen JH, Wong KH, Chan KC, Chen Z, Yam WC. Determination of the high prevalence of Dual/Mixed- or X4-tropism among HIV type 1 CRF01_AE in Hong Kong by genotyping and phenotyping methods. AIDS Res Hum Retroviruses. 2013 Aug;29(8):1123-8. doi: 10.1089/AID.2013.0067. Epub 2013 May 31. (Search PubMed)
- 這連結會以新視窗打開。Zhou J, Cheung AK, Liu H, Tan Z, Tang X, Kang Y, Du Y, Wang H, Liu L, Chen Z. Potentiating functional antigen-specific CD8⁺ T cell immunity by a novel PD1 isoform-based fusion DNA vaccine. Mol Ther. 2013 Jul;21(7):1445-55. doi: 10.1038/mt.2013.63. Epub 2013 Apr 16. (Search PubMed)
- 這連結會以新視窗打開。Zhou J, Cheung AK, Tan Z, Wang H, Yu W, Du Y, Kang Y, Lu X, Liu L, Yuen KY, Chen Z. PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice. J Clin Invest. 2013 Jun 3;123(6):2629-42. doi: 10.1172/JCI64704. Epub 2013 May 1. (Search PubMed)
- 這連結會以新視窗打開。Lam SK, Ng TB. Purification and characterization of an antifungal peptide with potent antifungal activity but devoid of antiproliferative and HIV reverse transcriptase activities from Legumi secchi beans. Appl Biochem Biotechnol. 2013 Apr;169(7):2165-74. doi: 10.1007/s12010-013-0129-y. Epub 2013 Feb 15. (Search PubMed)
- 這連結會以新視窗打開。Kang Y, Guo J, Chen Z. Closing the door to human immunodeficiency virus. Protein Cell. 2013 Feb;4(2):86-102. doi: 10.1007/s13238-012-2111-9. Epub 2013 Mar 12. (Search PubMed)
2012
- 這連結會以新視窗打開。Chen JH, Wong KH, Li PC, Chan KK, Lee MP, To SW, Yam WC. In-house human immunodeficiency virus-1 genotype resistance testing to determine highly active antiretroviral therapy resistance mutations in Hong Kong. Hong Kong Med J. 2012 Feb;18(1):20-4. (Search PubMed)
- 這連結會以新視窗打開。Lu X, Liu L, Zhang X, Lau TC, Tsui SK, Kang Y, Zheng P, Zheng B, Liu G, Chen Z. F18, a novel small-molecule nonnucleoside reverse transcriptase inhibitor, inhibits HIV-1 replication using distinct binding motifs as demonstrated by resistance selection and docking analysis. Antimicrob Agents Chemother. 2012 Jan;56(1):341-51. doi: 10.1128/AAC.05537-11. (Search PubMed)
2011
- 這連結會以新視窗打開。Woo PC, Lau SK, Liu B, Cai JJ, Chong KT, Tse H, Kao RY, Chan CM, Chow WN, Yuen KY. Draft genome sequence of Penicillium marneffei strain PM1. Eukaryot Cell. 2011 Dec;10(12):1740-1. doi: 10.1128/EC.05255-11. (Search PubMed)
- 這連結會以新視窗打開。Chen JH, Wong KH, Chan KC, To SW, Chen Z, Yam WC. Phylodynamics of HIV-1 subtype B among the men-having-sex-with-men (MSM) population in Hong Kong. PLoS One. 2011;6(9):e25286. doi: 10.1371/journal.pone.0025286. (Search PubMed)
2010
- 這連結會以新視窗打開。Chen JH, Wong KH, Chen Z, Chan K, Lam HY, To SW, Cheng VC, Yuen KY, Yam WC. Increased genetic diversity of HIV-1 circulating in Hong Kong. PLoS One. 2010 Aug 16;5(8):e12198. doi: 10.1371/journal.pone.0012198. (Search PubMed)
- 這連結會以新視窗打開。Mak WW, Cheung F, Woo J, Lee D, Li P, Chan KS, Tam CM.A comparative study of the stigma associated with infectious diseases (SARS, AIDS, TB). Hong Kong Med J. 2009 Dec;15 Suppl 8:34-7. (Search PubMed)
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這連結會以新視窗打開。Tsui SK, Fong NY, Li SK, Leung KK, Chan DP, Chan PK, Wong KH, Lee SS. Full Genome Analysis of an Emerging Cluster of Human Immunodeficiency Virus Type 1 Subtype B Infection in Hong Kong. AIDS Research and Human Retroviruses 2010; 26:117-122 (Search PubMed)
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這連結會以新視窗打開。Leung PH, Chen JH, Wong KH, Chan KC, Lam HY, Cheng VC, Yuen KY, Yam WC. High prevalence of primary Enfuvirtide (ENF) resistance-associated mutations in HIV-1-infected patients in Hong Kong. Journal of Clinical Virology 2010; 47:273-275 (Search PubMed)
2008
- 這連結會以新視窗打開。Chen JH, Wong KH, Chan KC, Lam HY, Yuen KY, Cheng VC, Yam WC. Molecular epidemiology and divergence of HIV type 1 protease codon 35 inserted strains among treatment-naive patients in Hong Kong. AIDS Research and Human Retroviruses 2008; 25:537-42. (Search PubMed)
- 這連結會以新視窗打開。Leung TW, Mak D, Wong KH, Wang Y, Song YH, Tsang DN, Wong C, Shao YM, Lim WL. Molecular Epidemiology Demonstrated Three Emerging Clusters of Human Immunodeficiency Virus Type 1 Subtype B Infection in Hong Kong. AIDS Research and Human Retroviruses 2008; 24(7):903-910 (Search PubMed)
2007
- 這連結會以新視窗打開。Lam HY, Chen JH, Wong KH, Chan K, Li P, Lee MP, Tsang DN, Yuen KY, Yam WC. Evaluation of NucliSens EasyQ HIV-1 assay for quantification of HIV-1 subtypes prevalent in South-east Asia. J Clin Virol. 2007 Jan;38(1):39-43. Epub 2006 Nov 15. (Search PubMed)
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這連結會以新視窗打開。Chen JH, Wong KH, Chan K, Lam HY, Lee SS, Li P, Lee MP, Tsang DN, Zheng BJ, Yuen KY, Yam WC. Evaluation of an in-house genotyping resistance test for HIV-1 drug resistance interpretation and genotyping. J Clin Virol. 2007 Apr 19. (Search PubMed)
2006
- 這連結會以新視窗打開。Tong K, He ML, Lin CK, Guo L, Kung HF, Sung JJ, Lee SS. The implications of a high allelic frequency of CYP2B6 G516T in ethnic Chinese persons. Clin Infect Dis. 2006 Aug 15;43(4):541-2. (Search PubMed)
- 這連結會以新視窗打開。He ML, Lin C, Tong K, Xu B, Sung JJ, Kung HF, Lee SS.Absence of CYP2B6 promoter -82T>C mutation in Chinese as an additional factor for slow metabolism of drugs commonly used in infections. Eur J Clin Pharmacol. 2006 Jul;62(7):585-586. (Search PubMed)
2005
- 這連結會以新視窗打開。Jones BM, Chiu SS, Wong WH, Lim WW, Lau YL. Cytokine profiles in human immunodeficiency virus-infected children treated with highly active antiretroviral therapy.MedGenMed. 2005 May 3;7(2):71. PMID: 16369449 [PubMed - indexed for MEDLINE] (Search PubMed)
- 這連結會以新視窗打開。Zhao XY, Lee SS, Wong KH, Chan KC, Ng F, Chan CC, Han D, Yam WC, Yuen KY, Ng MH, Zheng BJ. Functional Analysis of Naturally Occurring Mutations in the Open Reading Frame of CCR5 in HIV-Infected Chinese Patients and Healthy Controls. J Acquir Immune Defic Syndr 2005 Apr 15; 38(5):509-17. (Search PubMed)
2004
- 這連結會以新視窗打開。Zhao XY, Lee SS, Wong KH, Chan KC, He ZM, Ma S, Ng F, Chan CC, Ho T, Ng MH, Zheng BJ. A novel CCR5 mutation selectively affects immunoreactivity and fusogenic property of the HIV co-receptor. AIDS 2004 Aug 20; 18:1729-32. (Search PubMed)
- 這連結會以新視窗打開。Zhao XY, Lee SS, Wong KH, Chan KC, Ma S, Yam WC, Yuen KY, Ng MH, Zheng BJ. Effects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chinese. Eur J Immunogenet 2004 Aug; 31(4):179-83. (Search PubMed)
2001
- 這連結會以新視窗打開。Samaranayake YH, Samaranayake LP, Tsang PC, Wong KH, Yeung KW. Heterogeneity in antifungal susceptibility of clones of Candida albicans isolated on single and sequential visits from a HIV-infected southern Chinese cohort. J Oral Pathol Med 2001 Jul; 30(6):336-46. (Search PubMed)
- 這連結會以新視窗打開。Wong SS, Wong KH, Hui WT, Lee SS, Lo JY, Cao L, Yuen KY. Differences in Clinical and Laboratory Diagnostic Characteristics of Penicilliosis Marneffei in Human Immunodeficiency Virus (HIV)- and Non-HIV-Infected Patients. J Clin Microbiol 2001 Dec; 39(12):4535-40. (Search PubMed)
- 這連結會以新視窗打開。Kam KM, Leung WL, Wong KH, Lee SS, Hung MY, Kwok MY. Maturational changes in peripheral lymphocyte subsets pertinent to monitoring human immunodeficiency virus-infected Chinese pediatric patients. Clin Diagn Lab Immunol 2001 Sep; 8(5):926-31. (Search PubMed)
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